Utrozhestan and duphaston are hormonal drugs for maintaining pregnancy. Which is better - utrozhestan or duphaston? What is better progesterone or utrogestan

Preparations UTROZHESTAN and DUFASTON are usually prescribed to expectant mothers in the event of such a common problem as the threat of abortion. These drugs contain the hormone progesterone, under the influence of which important biological processes occur in the body of a woman, contributing to the successful bearing of the fetus.

The effect of progesterone on a woman's body is primarily aimed at providing favorable conditions for fertilization, attachment to the wall of the uterus and development of the fetal egg. The lack of production of this hormone often causes such an unfavorable episode of pregnancy as a miscarriage of the first trimester, because. it was during this period that the fetal egg had not yet attached to the uterus "tightly" and hormonal background mother is not fully formed and stable.

The hormone progesterone refers to progestogens - female sex hormones produced in the ovaries. Even before fertilization, he prepares the uterus for the adoption of the embryo, stimulates the development of the mammary glands. With a lack of progesterone, the mother's body gives the wrong signal to the immune system, as a result of which the fetus is perceived by the body as a foreign agent, and this leads to detachment of the trophoblast - the “leaf” that feeds the fetus, from which the placenta should form in the future. As a result, a first trimester miscarriage can occur.

Progesterone began to be used to treat the threat of abortion as early as the 60s and 70s of the last century, but at the same time, its side effects on the child and mother were fully manifested, in particular, fetal malformations could not be avoided. Only with the development of high technologies and the possibilities of using molecular methods of synthesis, it was possible to obtain drugs that can qualitatively and safely deal with this unfavorable moment of pregnancy. These drugs include DUFASTON and UTROZHESTAN.

DUFASTON

DUFASTON is a potent progestogen hormone. which, in its molecular structure and pharmacological action, is close to endogenous (i.e., produced by the body) progesterone and, as a result, has a high affinity for progesterone receptors (structures that perceive the action of this hormone), i.e. fits them perfectly, like a key to a lock.

A "synthetic" change in the configuration of the molecule leads to the fact that DUFASTON is easily absorbed when taken orally. Unlike many progestogen hormones, DUFASTON is not a derivative of the male hormone testosterone - its structure differs from the structure of most synthetic progestogens, as a result of which the drug is devoid of their characteristic side effects. Unlike other synthetic gestagens, DUFASTON:

does not cause the appearance of "female" signs in the male fetus and does not have a side effect on liver function and blood clotting;
does not cause such manifestations as acne, coarsening of the voice, hirsutism (increased hairiness) and masculinization of the genital organs (enlargement of the clitoris) in the female fetus;
does not cause changes in the lipid spectrum of blood and glucose concentration;
does not negatively affect other organs of internal secretion.

The high safety of DUFASTON, confirmed by many years of experience in its use (there was not a single case of intrauterine malformation of the fetus), allows you to confidently use the drug as a hormonal support. In addition, compared with UTROZHESTAN, dydrogesterone does not have a sedative (calming) effect. Sometimes this factor contributes to the fact that this drug is chosen for treatment.

Due to the unique correspondence to natural progesterone, DUFASTON recreates the natural mechanisms of the normal course of pregnancy. The results of many studies on this drug are inspiring: the use of DU-FASTON reduces the incidence of placental insufficiency and preterm birth by 2 times. And children are less likely to be underweight at birth, get a higher Apgar score (according to this scale, all newborns are evaluated, while paying attention to breathing, heartbeat, reflexes, skin, muscle tone). Newborns are less likely to experience hypoxic (i.e., associated with oxygen starvation) brain damage. The frequency of birth of healthy children increases by a third.

Of the side effects, in rare cases, uterine bleeding is possible (in this case, you should immediately consult a doctor). No other side effects have been identified with this drug.

The only significant contraindication for taking DUFASTON is hypersensitivity to the components of the drug, that is, individual intolerance.

DUFASTON (dydrogesterone) is a synthetic analogue of natural progesterone, UTROZHESTAN is natural progesterone. This is their main difference, which leads to some differences in the effects and use of these drugs.

Dydrogesterone is secreted from breast milk therefore, if it is necessary to use the drug during lactation, the doctor raises the question of stopping breastfeeding.

DUFASTON is especially often used when using IVF technology - in vitro fertilization. Numerous observations show that the use of a synthetic drug in IVF is more effective than a natural natural analogue, although large international studies on this subject have not been published. Long-term use of this drug in a large dose is possible due to the advantages of DUFASTON - high stable availability to tissues and the absence of side effects.

UTROZHESTAN

UTROZHESTAN is the only progesterone in the world produced from vegetable raw materials. This drug is a natural micronized, i.e. produced in a special form, progesterone (hormone molecules are surrounded by peanut butter). It is produced in the form of capsules for oral (by mouth) and intravaginal (in suppositories) use.

This drug has a complete resemblance to the progesterone molecule, and it is this property that provides a number of unique effects that distinguish it from other drugs in this group. UTROZHESTAN fully possesses the properties of endogenous (produced in the body) progesterone. It promotes pregnancy, prepares the endometrium for egg implantation. UTROZHESTAN (like DUFASTON) does not change body weight and does not contribute to fluid retention in the body, does not affect lipid and carbohydrate metabolism and does not increase blood pressure.

The unique structure of the UTROZHESTAN molecule allows it to influence the exchange of male androgen hormones (and they are also present in women during pregnancy). which not only has a positive effect on the course of pregnancy, but also improves skin condition.

UTROZHESTAN also has a positive effect when a woman has an increased amount of male sex hormones (hyperandrogenism) due to the fact that this drug interacts in the body with the same receptors as androgens, i.e. competes with them.

Another unique mechanism for UTROZHESTAN to maintain and maintain pregnancy is its ability to suppress the effects of oxytocin (this hormone is also produced by the ovaries, and it is he who stimulates uterine contractions and leads to miscarriage). This effect of UTROZHESTAN is especially pronounced when taken orally.

The usual dose of UTROZHESTAN is 200-300 mg per day, while any of the two routes of administration of the drug can be used - intravaginal or oral. When eliminating the threat of abortion, the combination of intravaginal administration of UTROZHESTAN with oral administration is more preferable and effective. It is important to note that the initial dose of UTROZHESTAN in case of a threatened miscarriage is 400-600 mg at once, followed by a maintenance dose of 400-600 mg per day. If this therapy is ineffective, the dose of UTROZHESTAN can be increased to 800-1000 mg per day. But the appointment of treatment, as well as changing the dose, should be carried out only by a doctor, since this is a hormonal drug, and its overdose or lack in the body can end tragically for pregnancy. Cancellation of UTROZHESTAN or a change in its dose is carried out under the control of various indicators of pregnancy, including the concentration of progesterone in the blood: it is normal pregnancy changes smoothly - and the cancellation should also occur without "bursts".

Let's say a few words about the side effects that may occur when taking this drug. Like "own" progesterone, UTROZHESTAN slightly increases body temperature and has a calming and hypnotic effect, more pronounced when taken orally. When taking the drug inside, drowsiness and dizziness may also occur.

In case of serious liver diseases, oral administration of UTROGEST is contraindicated - it is recommended to switch to intravaginal use, since the drug is actively metabolized (processed) by the liver.

In conclusion, let me remind dear mothers that if a doctor prescribes to a pregnant woman any of the drugs considered, this means a complete and serious treatment, since it is associated with the intake of hormones, minimal changes in the concentration of which in the blood (including without the knowledge of the doctor) in one direction or another can cancel out both the doctor's efforts and your pregnancy. Therefore, while taking these medicines, always keep a "hand on the pulse" - visit your doctor regularly and strictly follow his advice.

At the threat of interruption. They contain in their composition - the female sex hormone, which is produced in the ovaries. It affects important biological processes in a woman's body, providing conditions for a favorable conception and contributing to the successful bearing of the fetus. "Dufaston" and "Utrozhestan" are needed in order to, if necessary, make up for the lack of progesterone and help to deal with adverse moments of pregnancy in a quality and safe manner.

The cancellation of "Duphaston" and "Utrozhestan" or a change in their dose is carried out under the control of various indicators of pregnancy, including the concentration of progesterone in the blood.

What is "Duphaston"

This drug is a potent synthetic analogue of natural progesterone. It is easily absorbed in the gastrointestinal tract and has no side effects. "Dufaston" does not have a sedative effect, which is sometimes an important factor when choosing a drug. The unique correspondence of "Duphaston" to natural progesterone provides a natural mechanism for the normal course of pregnancy.

What are the benefits of "Utrozhestan"

This drug is the only one in the world made from natural raw materials. It fully possesses the properties of the hormone produced in the body. The drug promotes fertilization and prepares the uterus for implantation. An important advantage of Utrozhestan is that it is available not only in the form of oral capsules, but also vaginal ones, which is very convenient for toxicosis that bothers a pregnant woman. However, the drug has some side effects, including fatigue, drowsiness, and worsening mood.

The unique structure of the Utrozhestan molecule ensures the regulation of male sex hormones in a woman's body.

"Duphaston" or "Utrozhestan"?

These hormonal drugs do not affect carbohydrate and lipid metabolism and do not contribute to fluid retention in the body, which means that a woman will not get better when they are taken. In addition, they do not have a contraceptive effect and are not able to negatively affect ovulation. According to numerous patient reviews, each drug has its pros and cons, but which one is most suitable for a woman, the doctor decides individually. Thanks to Duphaston and Utrozhestan, many of the fair sex have the opportunity to experience the joy of motherhood.

Duphaston and Utrozhestan are hormonal medications that are widely used when there is a threat of abortion.

Expectant mothers are often interested in whether they are harmful to the baby and what is the difference between medicines. This is what we will try to understand in the presented article.

Utrozhestan - natural remedy, Duphaston - synthetic origin;
both drugs help to conceive a child and maintain a pregnancy;
Duphaston, unlike Utrozhestan, rarely leads to the development of adverse reactions;
positive side the purpose of Utrozhestan is that it can be used intravaginally;
the selection of the best drug should be done by the doctor, after assessing the position and characteristics of the patient.

Utrozhestan properties and instructions

Utrozhestan is a drug of natural origin, which helps to reduce the contractility of the endometrium. As a result, conditions conducive to conception are formed.

When administered orally, the maximum concentration of the active substance in the blood is observed after 3 hours, with vaginal administration, this period of time is reduced to an hour.

Indications

Utrozhestan is prescribed for:

amenorrhea;
infertility caused by imbalance of hormones;
neoplasms in the mammary glands of a fibrous nature;
conducting hormonal therapy;
the risk of preterm birth;
the need to normalize the level of lutein;
the threat of abortion.

Instructions for use

When diagnosing problems with conception, drugs are prescribed starting from the 17th day of the cycle, 200 mg for 14 days.

To prevent abortion, 200 mg of the drug is recommended to be injected into the vagina, it is better to do this at night. Treatment can continue from 22 to 34 weeks of pregnancy.

To normalize the indicators of lutein, the daily portion is sometimes increased to 400 mg. The duration of treatment, dose and route of administration is determined by the doctor for each case.

Side effects

The most common side effects include:

pain in the head;
flatulence;
drowsiness;
feeling of nausea;
vomiting;
diarrhea

The price of the drug

In pharmacies in Moscow, you can buy Utrozhestan at a cost of 390 rubles, it all depends on the manufacturer and dosage. In Ukraine, the tool will cost more than 400 hryvnia.

Dufaston properties and instructions

Dufaston is an artificial drug, it is available in tablet form.

Indications for use

The appointment of Duphaston is considered justified when:

painful periods;
endometritis;
problems with conception;
the threat of abortion;
the onset of menopause.

The drug can be prescribed when planning pregnancy, to restore hormonal balance.

Instructions for use

For problems with menstruation, the drug is prescribed 10 mg twice a day. The course of treatment begins on the 11th day of the cycle, and ends on the 25th.
In the case of diagnosing dysmenorrhea, Duphaston is taken 10 mg three times a day, starting from day 5 and ending on day 25 of menstruation.
For problems with conception, the drug is prescribed at a dose of 10 mg 1 time per day from the 14th to the 25th day of the cycle.
When there is a risk of abortion, Duphaston is used immediately at a loading dose of 40 mg, then 10 mg every 8 hours.
During menopause and bleeding, the dose is selected by the doctor.

Side effects

Adverse reactions when using Duphaston are rare, there may be:

decrease in hemoglobin and red blood cell count;
allergic reaction;
skin itching;
dysfunction of the liver.

The price of the drug

The cost of Duphaston on the territory Russian Federation is about 600 rubles. In Ukraine, the medicine can be purchased at a price of 300 hryvnia.

Comparative characteristics of the contraindications of drugs Duphaston and Utrozhestan

Duphaston should not be used in case of intolerance to its components, liver diseases, as well as during lactation.

The main contraindications for the use of Utrozhestan are:

bleeding;
an abortion that has begun;
neoplasms of the mammary glands of a malignant nature;
porphyria - liver disease of genetic origin;
allergy;
lactation.

With an increased level of thrombosis and serious problems with the functioning of the liver, the drug is prescribed only for vaginal use.

Utrozhestan or Duphaston when planning pregnancy: which is better

Utrozhestan is considered natural, but its intake often causes the development of adverse reactions. Data from observations and studies indicate that Duphaston is more effective in preparing for IVF.

It is necessary to focus on the fact that the selection of a drug that is better suited to a woman should be carried out by a doctor.

Utrozhestan or Duphaston: which is better during pregnancy and the threat of miscarriage

The issues of using Duphaston during pregnancy have been studied for a long time, which cannot be said about Utrozhestan, because this drug is younger. However, the positive side of the latter is that, in addition to oral administration, it can also be used intravaginally.

Utrozhestan is a remedy of natural origin, which is endowed with the ability to exert an antiandrogenic effect, which allows the fight against male hormones.

It helps to normalize the psycho-emotional state of a pregnant woman, and this is very important in such a period of life, and does not affect blood pressure and weight.

The positive aspects of using Duphaston are that it:

rarely causes the development of adverse reactions;
reduces the risk of abortion and premature birth;
does not adversely affect the liver of the expectant mother.

Summing up a little, I would like to note that there is no better drug, everything will depend on the case and the characteristics of the patient.

Quite often, in gynecology, drugs such as Duphaston and Utrozhestan are used, which, in fact, are complete analogues. The choice in prescribing one or the other is made by the doctor, taking into account the characteristics of the pathology, as well as the individuality of each organism. That is why, many women have a question regarding what are the benefits of each of them, and which drug is better: Duphaston or Utrozhestan, if we compare them.

What is Duphaston and how does it affect the body?

Dufaston refers to hormonal drugs. The active substance of this drug is progesterone, the molecules of which are very similar in structure to those produced by the female body.

This fact ensures easy digestibility of Duphaston by the body. The drug is well absorbed. Unlike other similar drugs containing progesterone, Duphaston contains a hormone that is not a derivative of the male sex androgen, which eliminates the development of side effects such as male pattern hair growth, coarsening of the voice, etc.

Features of the drug Utrozhestan

The main difference between Utrozhestan and Duphaston is the fact that the first is the only drug that contains progesterone, produced exclusively from plant materials.

The drug is actively used in preparing a woman for pregnancy, before carrying out. This drug is involved in the preparation of the uterine endometrium for a fertilized egg into it, which eliminates the risk of its rejection.

What is better to choose: Utrozhestan or Dufaston?

Having learned how Dufaston differs from Utrozhestan, women are wondering which is more effective: the first or the second?

This question cannot be answered unambiguously. At its core, these 2 drugs are absolutely interchangeable and are prescribed based on medical preferences, or features of pathology. Among the disadvantages of Duphaston, one can single out the fact that the drug has a sedative effect, i.e. after its application tends to sleep.

In addition, the advantage of Utrozhestan can also be called the fact that it suppresses the action of oxytocin, and as a result reduces uterine tone.

When choosing a drug (Dufaston or Utrozhestan) during pregnancy, due to the above fact, the choice is made in favor of the latter. At the same time, the gynecologist indicates the dosage and frequency of administration, taking into account all the features of a particular pathology.

Unfortunately, not all women can easily become pregnant and then bear a child without complications.

Due to strong hormonal changes in the body future mother different kinds of changes occur, provoking certain problems.

Quite often, in the first weeks of pregnancy, women experience placental abruption, an increased diagnosis, or a miscarriage occurs. The cause of these conditions is the lack of the hormone progesterone. Progesterone belongs to the category of gestagens, the adrenal glands, the corpus luteum of the ovaries and placental tissues are responsible for its production.

At the first signs of a threatened abortion: uterine tone, pulling pains in the lower abdomen, bloody discharge from the genital tract, progesterone preparations are prescribed, the most popular of which are Duphaston and Utrozhestan.

In our article, we will compare the drugs Utrozhestan and Dufaston, consider their advantages and disadvantages, indications and contraindications for use. Both medications are often prescribed already at the stage of pregnancy planning, since progesterone helps to conceive a baby with problems with its insufficiency.

It has a beneficial effect on the process of attaching the fetal egg to the wall of the uterus and the further bearing of the child, especially at the very beginning of pregnancy, when the immune system can perceive the fetus as a foreign organism and begin to reject it.

These drugs have a similar effect on the body, their main task is to help a woman become pregnant and maintain a pregnancy. But in order to find out what is better than Dufaston or Utrozhestan and how they differ from each other, it is necessary to consider each drug separately.

The composition of Duphaston and Utrozhestan and the release form

These hormonal drugs have an identical composition, but their main difference is that Duphaston is a synthetic drug, and Utrozhestan is natural. As part of Utrozhestan micronized progesterone, obtained from the leaves of the Dioscorea plant and close in formula to the natural one, which is produced by the female body.

Duphaston is an artificial analogue of progesterone, consists of dydrogesterone, also of plant origin, but subjected to more complex chemical processing. Utrozhestan is available in two forms: capsules for oral use (orally) and intravaginal suppositories. Duphaston is sold only in the form of tablets.

Indications for the use of Duphaston and Utrozhestan

Both drugs have similar indications for use. Utrozhestan is prescribed for the threat of spontaneous abortion, mild form, uterine fibroids, hormonal infertility (for example, caused by a cycle), and other gynecological diseases.

Also, the drug is very effective in the presence of high levels of male sex hormones in women. Utrozhestan is a fairly new drug, so in some European countries it is not yet widely used.

Duphaston was released by the pharmaceutical industry much earlier than Utrozhestan, and the experience of its use has a long history. The artificial configuration of the hormone allows the drug to quickly penetrate the body and be absorbed into the blood at the right concentration.

In addition to being used in case of a threatened miscarriage, Duphaston is also prescribed in preparation for in vitro fertilization, in case of violations menstrual cycle, dysfunctional uterine bleeding, replacement therapy after removal of the reproductive organs, infertility.

Conducted studies have shown that Duphaston several times reduces the risk of preterm birth in women who are registered with this problem.

Contraindications to taking Duphaston and Utrozhestan

Since Duphaston is a synthetic analogue of natural progesterone, its use is contraindicated in people with hypersensitivity to its constituents and other components of the drug. Duphaston is also not recommended for women with serious liver diseases (Rotor syndrome, Dubin-Johnson syndrome).

With caution and under the supervision of a physician, Duphaston is prescribed to patients with a history of itching during pregnancy. A contraindication to the use of Duphaston is the lactation period, since it penetrates into breast milk.

Utrozhestan, despite its naturalness, has much more contraindications for taking. Utrozhestan is not used for bleeding from the genital tract of an unknown nature, if the patient has malignant or reproductive organs, with certain liver diseases (porphyria), during an abortion in progress, with individual intolerance to the components of the drug.

With a tendency to the appearance of blood clots, an intravaginal method of using Utrozhestan is recommended. With caution, this remedy is prescribed to women in the 3rd trimester of pregnancy due to the risk of impaired liver function, as well as during breastfeeding.

Side effects of taking Duphaston and Utrozhestan

When taking Duphaston, the side effects of the patient are practically not noted. The only thing is that occasionally there are breakthrough uterine bleeding, which are eliminated by increasing the dose of the drug.

Utrozhestan has much more side effects, namely: dizziness 30-40 minutes after ingestion, lethargy, drowsiness, mood swings, increased fatigue. Some of them are eliminated by taking Utrozhestan vaginally.

What is better Duphaston or Utrozhestan

It is impossible to unequivocally answer the question of which drug is better than Duphaston or Utrozhestan. Each of them is prescribed by a doctor to a woman, taking into account specific indications, characteristics of the body, focusing on personal experience use or treatment outcomes of other patients.

Both drugs, although hormonal, do not affect body weight, since they do not lead to fluid retention in the body, which is especially important for pregnant women. These drugs do not affect the metabolism, they do not get fat from Duphaston and Utrozhestan.

A big plus is that the drugs also do not lead to an increase in blood pressure. But still, both drugs have their pros and cons, as well as advantages over each other.

Why Duphaston is better than Utrozhestan:

few side effects;
minimal impact on the liver;
high efficiency in planning a child with the help of IVF (good indicators of fetal survival);
probability reduction;
no side effects on the fetus;
no contraindications to driving while taking Duphaston;
Duphaston is a more researched drug;
Duphaston can be taken for a longer time, unlike Urozhestan

Advantages of Utrozhestan:

a natural drug that is closest in composition to natural progesterone;
the ability to use the drug both orally and intravaginally (especially method 2 is suitable for pregnant women with strong);
effective with an excess of male hormones;
does not have a harmful effect on the fetus;
low cost of Utrozhestan compared to Duphaston

Which drug is best for you, you can only evaluate on your own experience. In general, they both do a good job with their functions: they compensate for the deficiency of progesterone in the body, bring the uterus back to normal, eliminating manifestations, reduce the likelihood of miscarriage, and normalize the cycle.

Interchangeability of Duphaston and Utrozhestan

A large number of women are interested not only in the question of which of these means is better, but also whether it is possible to replace Utrozhestan with Dufaston and vice versa. The substitution of one drug for another is different reasons: some patients may have contraindications to taking a particular remedy, others may have individual intolerance to the components, others generally just want to receive Duphaston in a women's consultation for a free prescription.

It is categorically impossible to prescribe Dufaston or Utrozhestan to yourself, or to replace one remedy with another. Hormonal drugs require strict adherence to instructions and smooth cancellation or transition, therefore, the scheme for switching from Duphaston to Utrozhestan or vice versa for each patient is selected by the doctor individually, taking into account the characteristics of the woman's body, contraindications to taking hormones and pregnancy management.

As a rule, Utrozhestan is usually prescribed to patients in the first trimester (less often in the second) because of the convenience of its use in the form of vaginal capsules, especially with severe preeclampsia in pregnant women. Duphaston can be prescribed at any stage of pregnancy if there is a threat of miscarriage or, according to the results of the analysis, the woman has a clear progesterone deficiency.

How to take Duphaston and Utrozhestan

The regimens for taking Duphaston and Utrozhestan for various diseases and pathologies, as well as during pregnancy, are different and are selected individually by a specialist.

To normalize the cycle, Utrozhestan is usually prescribed 200 mg 2 times a day in the morning and evening for 10 days. With the threat of miscarriage during pregnancy, a dose of Utrozhestan is prescribed, equal to 200-600 mg per day. In other pathological conditions, the drug is recommended to take from 200 to 400 mg.

The dosage of Duphaston in each case is selected individually. In case of cycle disorder and premenstrual syndrome, the drug is prescribed 1 tablet 2 times a day for 2 weeks, starting from the 11th day of the cycle, with infertility caused by luteal phase deficiency, Dufaston is drunk from the 14th to the 25th day of the cycle, 1 tablet per day, with threatening abortion, 4 tablets are prescribed once, then 1 every 8 hours until disappearance anxiety symptoms etc.

In the case of prescribing progesterone drugs during the planning of a child, a woman often continues to take them for almost the entire pregnancy, since the body is accustomed to the intake of hormones from the external environment and does not cope well with its production in a natural way.

Sometimes the doctor may prescribe the patient the simultaneous use of Duphaston and Utrozhestan in order to minimize the likelihood of developing individual side effects associated with long-term use of hormonal drugs. Often, Duphaston is prescribed to a woman orally in addition to the intravaginal use of Utrozhestan.

This regimen allows you to maintain the required level of the pregnancy hormone progesterone is normal with minimal risks for the expectant mother and fetus. The main thing is to follow the instructions and dosage indicated by the gynecologist.

Cancellation of drugs

On the later dates pregnancy, when the placenta is fully formed and is itself able to produce the right amount of progesterone, Duphaston or Utrozhestan are canceled. But in the presence of a prolonged threat of termination of pregnancy, the appearance of pulling pains in the lower abdomen and uterine tone after the abolition of progesterone, Duphaston continues to be taken further.

Utrozhestan is replaced by Duphaston, since it has a negative effect on the liver at the end of the II and III trimesters of pregnancy. The scheme for canceling Duphaston and Utrozhestan is approximately the same - a gradual reduction in the dose of the drug (half a tablet per week or another option suggested by the doctor) with an assessment of the patient's condition.

If Duphaston and Utrozhestan stop taking very abruptly, serious consequences are possible, up to a miscarriage on early term pregnancy and premature birth at a later date. Be careful with taking hormonal drugs and take them only as directed by your doctor.